RI-STAD 2 ( )

Catalog No. M30818 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RI-STAD 2
Note

Research use only, not for human use.
Brief Description

AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable.
Description

AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable.
Synonyms
Pathway

Others
Target

Other Targets
Recptor

——
Research Area

——
Indication

——

CAS Number

--
Formula Weight

2401.8
Molecular Formula

C109H181N25O35
Purity

>98% (HPLC)
Solubility

50% acetonitrile / water:1 mg/mL
SMILES

O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@](CCC/C=C/CCC[C@](NC([C@H](CC(C)C)NC(COCCOCCOCCN)=O)=O)(C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@H]2C)=O)=O)=O)C)(NC2=O)C
Chemical Name

1. Wang et al (2015) PKA-type I selective constrained peptide disruptors of AKAP complexes. ACS Chem.Biol. 10 1502 PMID:

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